By Andrej Čretnik
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Additional info for Achilles Tendon
This is a less discussed and appreciated application. It is however currently an important application of this area of research. Some of the previously reported associated genetic markers are functional. It is therefore possible to postulate how these genes, or more specifically their protein products are involved in the etiology of the injuries. These possible mechanism need to be proved or verified using other biological techniques. As previously reviewed (Collins 34 Achilles Tendon & Posthumus, In Press) work is currently ongoing to explain how variants within the 3’UTR of the COL5A1 gene could be directly involved in the susceptibility to Achilles tendon injuries.
Patterson-Kane JC, Wilson AM, Firth EC, Parry DA, Goodship AE. Comparison of collagen fibril populations in the superficial digital flexor tendons of exercised and nonexercised thoroughbreds. Equine Vet J 29: 121–125, 1997. Proske U, Morgan DL. Tendon stiffness: methods of measurement and significance for the control of movement. J Biomech 20: 75–82, 1987. Purslow PP. The structure and functional significance of variations in the connective tissue within muscle. Comp Biochem Physiol A Mol Integr Physiol 133: 947–966, 2002.
2004). Within the fascicles there exist specialized fibroblasts called tenocytes, which exhibit a high degree of organization. Vertically they appear star-like and longitudinally they appear to be arranged in a row along the fibers. This special orientation of the cells reflects their function. , 1996). The fascicles are covered with epitenon, which in turn is covered with paratenon. A fluid film lies between these two layers, which make the movements of the tendon possible. 2 Tendon healing Study of the physiology of tendon healing has revealed two mechanisms of healing, intrinsic and extrinsic healing (Grotendorst, 1988; Hefti & Stoll 1995).
Achilles Tendon by Andrej Čretnik